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KMID : 1137820090300020113
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의공학회지
2009 Volume.30 No. 2 p.113 ~ p.121
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Development and Evaluation of Multi-Wavelength Excitation light Source for Fluorescence Imaging to Diagnose Malignancies
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Lim Hyun-Soo
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Abstract
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This study aims at designing and evaluating light source devices that can stably generate light with various wavelengths in order to make possible PDD using a photosensitizer and diagnosis using auto-fluorescence. The light source was a Xenon lamp and filter wheel, composed of an optical output control through Iris and filters with several wavelength bands. It also makes the inducement of auto-fluorescence possible because it is designed to generate a wavelength band of 380-420nm, 430-480nm, and 480-560nm. The transmission part of the light source was developed to enhance the efficiency of light transmission. To evaluate this light source, the characteristics of light output and wavelength band were verified. To validate the capability of this device as PDD, the detection of auto-fluorescence using mouse models was performed.
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KEYWORD
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PDD, fluorescence diagnosis, cancer, 5-ALA, PPIX, photosensitizer, Auto-fluorescence
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